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OCR: In keeping with the observation that th ects on hypothalamus exerts tonic inhibitory ef ade prolactin secretion, is the finding that cr lease. Thishypothalamic extracts inhibit prolactin $ (1966). PIF bioactivity has been termed PIF by Meite (1971), has been identified in portal vessel bloo nents for thus satisfying one of the critical require proof of physiological significance of a a number hypophysiotrophic hormone. Although lease have of substances that can inhibit prolactin r ost been isolated from the hypothalamus, n ncipal workers believe that dopamine is the pr facto: